Akt-ing Up on SRPK1: Oncogene or Tumor Suppressor?

作者：Toker Alex^*; Chin Y Rebecca

来源：Molecular Cell, 2014, 54(3): 329-330.

DOI：10.1016/j.molcel.2014.04.020

In this issue of Molecular Cell, Wang et al. (2014) report that the splicing kinase SRPK1 can function as both an oncogene and a tumor suppressor by modulating the activation state of the protein kinase Akt. This is shown to be mediated by the ability of SRPK1 to bind to the Akt phosphatase PHLPP1.

• 出版日期2014-5-8