Autoimmune Hemolytic Anemia in Patients with β-Thalassemia Major

作者：Xu, Lu-Hong; Fang, Jian-Pei^*; Weng, Wen-Jun; Huang, Ke; Zhang, Ya-Ting

来源：Pediatric Hematology and Oncology, 2012, 29(3): 235-240.

DOI：10.3109/08880018.2012.666782

• autoimmune hemolytic anemia
• clinical feature
• management
• thalassemia

Hemolysis is a common feature in patients with beta-thalassemia major. As a result, autoimmune hemolytic anemia complicating beta-thalassemia is easily overlooked. Here, the authors described the clinical features and management of 7 patients with beta-thalassemia major and autoimmune hemolytic anemia. These patients had fever, cough, and tea-colored urine on admission. The laboratory investigations showed a significant drop in hemoglobin and increased serum bilirubin. Coombs' tests revealed that anti-immunoglobulinG(IgG) and anti-C3 was positive in 7 and 5 cases, respectively, whereas anti-Rh E alloantibody was positive in 3 cases. All the patients received corticosteroids treatments and blood transfusions. Patients with anti-Rh E alloantibodies also received immunoglobulin treatments. Six of the patients responded well to the management, but 1 patient developed recurrent autoimmune hemolytic anemia that required cyclosporin A treatment. All the patients remained well by following up for more than 6 months.

• 出版日期2012-4
• 单位中山大学