Allergic rhinitis and risk of erectile dysfunction - a nationwide population-based study

作者：Su V Y F; Liu C J; Lan M Y; Chen Y M; Su K C; Lee Y C; Chen T J; Chou K T^*

来源：Allergy, 2013, 68(4): 440-445.

DOI：10.1111/all.12100

• allergic rhinitis
• erectile dysfunction
• male sexual impotence
• systemic inflammation

Background A growing body of evidence has disclosed that allergic rhinitis (AR) is a systemic inflammatory disease. Inflammatory mediators and cells involved in AR have also been reported to be implicated in the process of atherosclerosis, which is relevant to the occurrence of erectile dysED). Our objective was to explore the relationship between AR and future ED events. Methods From 1 January 2000 to 31 December 2008, we identified male patients, who were aged 1855years and newly diagnosed with AR from the Taiwan National Health Insurance Research Database. A control cohort without AR, which was matched for age, comorbidities and medications, was selected for comparison. The two cohorts were followed up until 31 December 2009 and observed for occurrence of ED by registry of ED diagnosis in the database. Results Of the 128118 sampled male patients (64059 AR patients vs 64059 matched controls), 1455 (1.16%) experienced ED during a mean follow-up period of 5.82years, including 844 (1.32% of the AR patients) from the AR cohort and 611 (0.95%) from the controls. KaplanMeier analysis revealed a tendency of AR patients to develop ED (log-rank test, P%26lt;0.001). After adjusting confounder variables by Cox regression, subjects with AR experienced a 1.37-fold (95% CI, 1.241.52; P%26lt;0.001) increase in incident ED. The risk of ED was higher in cases with more frequent clinical visits for AR and in cases needing medication more than 4weeks. Conclusions Patients with AR appeared to be at higher risk of future ED, possibly in a severity-dependent manner.

• 出版日期2013-4