Autism Spectrum Disorders and Autisticlike Traits Similar Etiology in the Extreme End and the Normal Variation

作者：Lundstrom Sebastian^*; Chang Zheng; Rastam Maria; Gillberg Christopher; Larsson Henrik; Anckarsater Henrik; Lichtenstein Paul

来源：Archives of General Psychiatry, 2012, 69(1): 46-52.

DOI：10.1001/archgenpsychiatry.2011.144

Context: Autism spectrum disorders (ASDs) have been suggested to represent the extreme end of a normal distribution of autisticlike traits (ALTs). However, the evidence of this notion is inconclusive. %26lt;br%26gt;Objective: To study whether there are similar genetic and/or environmental etiologies behind ASDs and ALTs. %26lt;br%26gt;Design: A nationwide twin study. %26lt;br%26gt;Participants: Consenting parents of all Swedish twins aged 9 and 12 years, born between July 1, 1992, and December 31, 2001 (n=19 208), were interviewed by telephone to screen for child psychiatric conditions, including ASDs. %26lt;br%26gt;Main Outcome Measures: Two validated cutoffs for ASDs, 2 cutoffs encompassing the normal variation, and 1 continuous measure of ALTs were used with DeFries-Fulker extreme-end analyses and standard twin study methods. %26lt;br%26gt;Results: We discerned a strong correlation between the 4 cutoffs and the full variation of ALTs. The correlation was primarily affected by genes. We also found that the heritability for the 4 cutoffs was similar. %26lt;br%26gt;Conclusion: We demonstrate an etiological similarity between ASDs and ALTs in the normal variation and, with results from previous studies, our data suggest that ASDs and ALTs are etiologically linked.

• 出版日期2012-1