Advances in pharmacological strategies for the prevention of cataract development

作者：Gupta S K; Selvan V Kalai; Agrawal S S; Saxena Rohit

来源：Indian Journal of Ophthalmology, 2009, 57(3): 175-183.

DOI：10.4103/0301-4738.49390

• Aldose reductase
• antioxidants
• glutathione
• vitamins

Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. The article also reviews research on potential anticataractous agents, including aldose reductase inhibitors, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources.

• 出版日期2009-6
• 单位河北医科大学