A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy

作者：Zhang, Ying; Shu, Chunying; Zhen, Mingming^*; Li, Jie; Yu, Tong; Jia, Wang; Li, Xue; Deng, Ruijun; Zhou, Yue; Wang, Chunru^*

来源：Science China-Materials, 2017, 60(9): 866-880.

DOI：10.1007/s40843-017-9079-6

• gadofullerene nanocrystals
• chemopreventive agent
• myelosuppression
• radical scavenging
• chemotherapy drug

Chemotherapy as an effective cancer treatment technique has been widely used in tumor therapy. However, it is still a challenge to overcome the serious side effects of chemotherapy, especially for its myelotoxicity. Here we report a novel strategy using the water soluble gadofullerene nano-crystals (GFNCs) to protect against chemotherapy injury in hepatocarcinoma bearing mice, which was induced by the commonly chemotherapeutic agent cyclophosphamide (CTX). The GFNCs were revealed to specifically accumulate in the bone marrow after intravenously injecting to mice and they exhibited excellent radical scavenging function, resulting in a prominent increase of mice blood cells and pathological improvements of the primary organs in the GFNCs (15 mg kg(-1)) treated mice after the CTX (60 mg kg(-1)) therapy. Moreover, the GFNCs maintained and even strengthened the antineoplastic activity of the CTX agent. Therefore, the GFNCs would be the promising chemoprotective agents in chemotherapy based on their high efficiency, low toxicity and metabolizable property.

• 出版日期2017-9
• 单位中国科学院大学