Mechanistic insights into cellular immunity of chondroitin sulfate A and its zwitterionic N-deacetylated derivatives

作者：Zhang, Wuxia; Sun, Feifei; Niu, Hong; Wang, Qingjie; Duan, Jinyou^*

来源：Carbohydrate Polymers, 2015, 123: 331-338.

DOI：10.1016/j.carbpol.2015.01.059

• Chondroitin sulfate
• Polysaccharide
• N-Deacetylation
• Immune response

As a major component in extracellular matrix of the tissue, chondroitin sulfate A (CS-A) has been shown to exhibit either pro- or anti-inflammatory immune response which was largely dependent on its molecular size and cell types. In this study, we determined the signaling pathway involved in immune response of CS and its N-deacetylated derivative (dCS). Our data indicated that both CS and dCS could activate the NF-kappa B transcription factor in antigen presenting cells and induce TNF-alpha production through the TLR/MyD88 pathway. Further studies demonstrated that both CS and dCS had a potential in promoting the proliferation of spleen lymphocytes, and promoting the cytokines secretion by OVA-sensitized splenocytes. Thus, our finding provided a mechanistic insight into the understanding of cellular immunity of CS and dCS, which might be helpful to develop CS-based immune modulators against chronic inflammatory conditions, autoimmunity, infectious diseases, allergies and asthmatic conditions.

• 出版日期2015-6-5
• 单位西北农林科技大学