A functionalized cobalt(III) mixed-polypyridyl complex as a newly designed DNA molecular light switch

作者：Zhang, QL^*; Liu, JH; Ren, XZ; Xu, H; Huang, Y; Liu, JZ; Ji, LN

来源：Journal of Inorganic Biochemistry, 2003, 95(2-3): 194-198.

DOI：10.1016/S0162-0134(03)00122-3

• cobalt(III) complex
• DNA
• molecular light switch

The ligand ODHIP (3,4-dihydroxyl-imidazo[4,5-f][1,10]phenanthroline) and its cobalt(III) complex [Co(bpy)(2)(ODHIP)](3 ) were synthesized and characterized. Binding of this complex with calf thymus DNA has been investigated by spectroscopic methods and viscosity. The experimental results indicated that the complex bound to DNA by intercalation. In Tris buffer, the complex could emit relatively weak luminescence. After binding to DNA, the notable enhancement was observed. However, when the Cu2 was further added, the luminescence decreased gradually and disappeared after the equimolar concentrations of Cu2 was added, which exhibited the "off-on-off" properties of molecular light switch.

• 出版日期2003-6-1
• 单位深圳大学; 中山大学