Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis

作者：van Schinkel Linda D^*; Auger Dominique; van Elderen Saskia G C; Marsan Nina Ajmone; Delgado Victoria; Lamb Hildo J; Ng Arnold C T; Smit Johannes W A; Bax Jeroen J; Westenberg Jos J M; de Roos Albert

来源：International Journal of Cardiovascular Imaging, 2013, 29(3): 633-641.

DOI：10.1007/s10554-012-0125-2

• Cardiovascular magnetic resonance imaging
• Diabetes mellitus type 1
• Aortic stiffness
• Echocardiography
• Cardiac diastolic function

Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle tracking strain analysis in patients with DM1. Aortic PWV was assessed with cardiovascular magnetic resonance in 41 DM1 patients. Patients underwent echocardiography for assessment of conventional LV diastolic function indices and LV and LA longitudinal strain and strain rate (SR) assessed with speckle tracking strain analysis. LV SR during the isovolumic relaxation period (SRIVR) and LA strain were recorded and the E-wave velocity to SRIVR velocity ratio (E/SRIVR) was calculated. Independent samples t test and multivariate linear regression analyses were used for statistical analyses. Aortic PWV significantly correlated with SRIVR (beta = -0.71, p %26lt; 0.001), E/SRIVR (beta = 0.61, p = 0.002) and LA strain (beta = -0.47, p = 0.014), but not with conventional echocardiographic markers of diastolic all p %26gt; 0.10). In DM1 patients, aortic stiffness is inversely associated with sensitive markers of LV diastolic function and decrease in LA compliance as measured with echocardiographic speckle tracking strain analysis.

• 出版日期2013-3