Analysis of correlations between N-terminal pro-B-type natriuretic peptide levels and markers of venous pulmonary hypertension in patients referred for heart transplantation

作者：Wierzbicki Karol^*; Sobczyk Dorota; Bochenek Maciej; Milaniak Irena; Ciolczyk Wierzbicka Dorota; Wegrzyn Piotr; Bartus Krzysztof; Przybylowski Piotr; Kapelak Boguslaw; Drwila Rafal; Sadowski Jerzy

来源：Polish Archives of Internal Medicine, 2012, 122(6): 291-297.

DOI：10.20452/pamw.1289

• heart failure
• heart transplantation
• NT-proBNP
• secondary venous pulmonary hypertension

INTRODUCTION Heart failure (HF) is a growing health care problem in the world. Secondary pulmonary venous hypertension is usually observed in patients with end-stage heart failure. %26lt;br%26gt;OBJECTIVES The main purpose of the study was to evaluate the relationships between N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and the markers of secondary venous pulmonary hypertension in patients referred for heart transplantation (HTX). %26lt;br%26gt;PATIENTS AND METHODS This retrospective analysis included 35 patients (32 men, 3 women; median age, 55.0; interquartile range [IQR] 12.0 years). The study group consisted of all consecutive patients referred for HTX, in whom the right-heart catheterization using the Swan-Ganz catheter was performed at the same time as the measurement of NT-proBNP levels. %26lt;br%26gt;RESULTS A high median value of NT-proBNP (3187.0; IQR 2964.0 pg/ml) and elevated pulmonary pressure were observed in the study group. There was a significant correlation between NT-proBNP levels and the values of systolic, mean, and diastolic pulmonary artery pressure (r = 0.5, P = 0.001; r = 0.5, P = 0.001; r = 0.5, P = 0.002; respectively) as well as cardiac output (r = -0.4, P = 0.007). There was also a positive correlation between pulmonary artery resistance and NT-proBNP levels (r = 0.5, P = 0.006). %26lt;br%26gt;CONCLUSIONS In our study population, the median value of NT-proBNP levels exceeded the normal range 25 times. There was a correlation between the markers of secondary pulmonary hypertension and cardiac output and NT-proBNP levels. Elevated NT-proBNP levels in patients with end-stage HF may be associated with significant secondary venous pulmonary hypertension.

• 出版日期2012