Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review

作者：Macone Alberto; Fontana Mario; Barba Marco; Botta Bruno; Nardini Mirella; Ghirga Francesca; Calcaterra Andrea; Pecci Laura; Matarese Rosa Marina^*

来源：International Journal of Molecular Sciences, 2011, 12(5): 3072-3084.

DOI：10.3390/ijms12053072

• sulfur-containing antioxidants
• aminoethylcysteine ketimine decarboxylated dimer
• reactive oxygen species
• reactive nitrogen species

Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.

• 出版日期2011-5