Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

作者：Shi, Zhe-Min; Han, Ya-Wei; Han, Xiao-Hui; Zhang, Kun; Chang, Ya-Nan; Hu, Zhi-Mei; Qi, Hai-Xia; Ting, Chen; Zhen, Zhang; Hong, Wei^*

来源：Journal of the Neurological Sciences, 2016, 366: 127-134.

DOI：10.1016/j.jns.2016.05.022

• NF-kappa B
• Alzheimer's disease
• ROS
• TNF-alpha
• TGF-beta
• A beta
• microRNA
• PI3K/AKT
• MAPK
• AGE/RAGE/GSK-3

Since Alzheimer's disease (AD) is becoming the prevalent dementia in the whole world, more underlying mechanisms are emerging. Long time has the transcription factor NF-kappa B been identified to participate in AD pathogenesis, various studies have focused on the causes and effects of AD that are linked to NF-kappa B. In this review we discuss diverse environmental stimuli including oxidative stress, neuroinflammation and metabolism, involved signaling pathways such as PI3K/AKT, MAPK and AGE/RAGE/GSK-3 and newly found ncRNAs that mediate neuron toxicity or neuron protection through NF-kappa B activation and the following response associated with the same factors in AD. These may provide future orientation of investigation at transcription level and support efficient treatment to AD by a better understanding of the upstream regulators and downstream effectors of NF-kappa B.

• 出版日期2016-7-15
• 单位天津医科大学