An efficient route to diverse 2H-pyrano[3,2-c]quinolin-5(6H)-ones via electrophilic cyclization reactions

作者：Chen, Zhen; Wang, Zhiyong^*

来源：Tetrahedron, 2016, 72(29): 4288-4293.

DOI：10.1016/j.tet.2016.05.075

• 2H-Pyrano[3,2-c]quinolin-5(6H)-one
• Electrophilic cyclization
• Iodocyclization
• Iodine
• Cross-coupling reactions

Electrophilic cyclization of 4-((3-arylprop-2-yn-1-yl)oxy)guinolin-2(1H)-one derivatives with iodine leads to the formation of 2H-pyrano[3,2-c]guinolin-5(6H)-ones bearing an alkenyl iodide moiety in good to excellent yields under mild conditions. The resulting iodo-containing 2H-pyrano[3,2-c]quinolin-5(6H)-ones could be further elaborated via palladium-catalyzed cross-coupling reactions.

• 出版日期2016-7-21
• 单位山东第一医科大学; 重庆大学