Divergent neuroendocrine responses to localized and systemic inflammation

作者：Lukewich Mark K; Rogers Richard C; Lomax Alan E^*

来源：Seminars in Immunology, 2014, 26(5): 402-408.

DOI：10.1016/j.smim.2014.01.004

• Neuroimmunology
• Sympathetic nervous system
• Sepsis
• Inflammatory bowel disease
• Excitation secretion coupling

The sympathetic nervous system (SNS) is part of an integrative network that functions to restore homeostasis following injury and infection. The SNS can provide negative feedback control over inflammation through the secretion of catecholamines from postganglionic sympathetic neurons and adrenal chromaffin cells (ACCs). Central autonomic structures receive information regarding the inflammatory status of the body and reflexively modulate SNS activity. However, inflammation and infection can also directly regulate SNS function by peripheral actions on postganglionic cells. The present review discusses how inflammation activates autonomic reflex pathways and compares the effect of localized and systemic inflammation on ACCs and postganglionic sympathetic neurons. Systemic inflammation significantly enhanced catecholamine secretion through an increase in Ca2+ release from the endoplasmic reticulum. In contrast, acute and chronic GI inflammation reduced voltage-gated Ca2+ current. Thus it appears that the mechanisms underlying the effects of peripheral and systemic inflammation neuroendocrine function converge on the modulation of intracellular Ca2+ signaling.

• 出版日期2014-10