Novel components of the human metabolome: The identification, characterization and anti-inflammatory activity of two 5-androstene tetrols

作者：Ahlem Clarence N^*; Page Theodore M; Auci Dominick L; Kennedy Michael R; Mangano Katia; Nicoletti Ferdinando; Ge Yu; Huang Yujin; White Steven K; Villegas Sonia; Conrad Douglas; Wang Angela; Reading Christopher L; Frincke James M

来源：Steroids, 2011, 76(1-2): 145-155.

DOI：10.1016/j.steroids.2010.10.005

• Androstene
• Tetrol
• Metabolism
• Inflammation
• Metabolome
• Human

Two natural 5-androstene steroid tetrols, androst-5-ene-3 beta,7 beta,16 alpha,17 beta-tetrol (HE3177) and androst-5-ene-3 alpha,7 beta,16 alpha,17 beta-tetrol (HE3413), were discovered in human plasma and urine. These compounds had significant aqueous solubility, did not bind or transactivate steroid-binding nuclear hormone receptors. and were not immunosuppressive in murine mixed-lymphocyte studies. Both compounds appear to be metabolic end products, as they were resistant to primary and secondary metabolism. Both were orally bioavailable, and were very well tolerated in a two-week dose-intensive toxicity study in mice. Anti-inflammatory properties were found with exogenous administration of these compounds in rodent disease models of multiple sclerosis, lung injury, chronic prostatitis, and colitis.

• 出版日期2011-1