Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

作者：Domach Michael M^*; Walker Lynn M

来源：Journal of the Association for Laboratory Automation, 2010, 15(2): 136-144.

DOI：10.1016/j.jala.2010.01.002

• hydrogels
• block copolymers
• protein aggregation
• antibodies
• protein stability

Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field. (JALA 20 I 0;15:136-44)

• 出版日期2010-4