Antioxidant vitamin levels in sickle cell disorders

作者：Ray Debes; Deshmukh Pradeep; Goswami Kalyan; Garg Neelam^*

来源：National Medical Journal of India, 2007, 20(1): 11-13.

Background Sickle cell disorder is a haemoglobinopathy prevalent In the Vidharbha region of Maharashtra, central India. With recent evidence of oxidative stress in sickle haemoglobinopathy, a possible deficiency of antioxidant vitamins was suspected.
Methods. We measured plasma vitamin E, vitamin C and beta-carotene levels in persons with heterozygous (n=80) and homozygous sickle cell state (n=20), and suitable healthy controls for these groups (n=100 and 66, respectively) in a community-based study in the villages near our institution.
Results. Subjects with heterozygous sickle cell trait had lower vitamin E levels than their respective controls (p < 0.05). Subjects with homozygous sickle cell disease had lower levels of all three vitamins (p < 0.05). Vitamins E and C levels showed a significant positive correlation in both forms of sickle cell disorder.
Conclusion. Our findings suggest that there is depletion of the antioxidant vitamins, particularly in severe forms of sickle cell disorder. A trial of administration of therapeutic doses of vitamin E in this condition is warranted.

• 出版日期2007-2
• 单位河北医科大学