Asymmetric Synthesis of (-)-Swainsonine

作者：Tian Yong Shou; Joo Jae Eun; Kong Bae Soo; Pham Van Thoai; Lee Kee Young; Ham Won Hun^*

来源：Journal of Organic Chemistry, 2009, 74(10): 3962-3965.

DOI：10.1021/jo802800d

We report a new asymmetric synthetic method for (-)swainsonine utilizing a chiral oxazoline precursor. The key features in this strategy are the diastereoselective oxazoline formation reaction catalyzed by palladium(0), diasteroselective dihydroxylation, and the stereocontrolled allylation reaction with TiCl(4).

• 出版日期2009-5-15