A Retrospective Study on Clinical Characteristics of Paediatric Crohn's Disease

作者：Wu D Z; Chen C D^*; Wu S C; Dai L N; Xia L G; Chen X M

来源：Hong Kong Journal of Paediatrics, 2014, 19(3): 169-174.

• China
• Crohn's disease
• Paediatric

Objectives: The aim of this study is mainly to describe the clinical pattern of paediatric Crohn's disease (CD) and improve diagnostic accuracy and therapeutic efficacy. Methods: CD patients between the ages of 0 and 18 years old were identified by survey of computerised medical information. Twenty cases were selected for this retrospective study. Results: The median age at diagnosis was 9.4 years (range, 25 days 17 years). The peak prevalence of CD was observed in the 10-14 years old age group. Sixty (50%) were males. All the children are Han Chinese ethnicity. The most common presenting symptoms was diarrhoea (70%), fever (60%), abdominal pain (55%) and bloody stool (10%). At least one extra-intestinal manifestations occurred in 35% of Crohn's disease patients. Growth retardation is another common complication, which is presented in 50% of patients. The most common distribution were ileo-colon (45%) and colon (35%). Perianal disease also occurred in 25% children with CD. According to the laboratory findings, anaemia presented in 70% patients, thrombocytosis presented in 70% and hypoalbuminaemia presented in 65%. Three patients underwent the surgery, after which death was caused in 2 cases. Conclusion: The clinical features of paediatric Crohn's disease are found to be complicated and nonspecific. Recognition of CD by paediatricians is necessary for proper diagnosis and management.

• 出版日期2014-7
• 单位温州医科大学