Association of gene polymorphisms in toll-like receptors 4 with bacterial infection after orthotopic liver transplantation in Han Chinese patients

作者：Yang, Fu; Li, Hao; Pu, Ying; Wang, Chunguang; Fan, Junwei; Xing, Tonghai; Peng, Zhihai; Fang, Fang^*; Zhong, Lin^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(5): 8174-8182.

• Toll-like receptor 4
• single nucleotide polymorphism
• bacterial infection
• liver transplantation

Bacterial infections represent the most common complications after liver transplantation (LT). Toll-like receptor 4 (TLR4) plays a pivotal role in recognizing pathogens. The study aimed to determine the association between TLR4 single nucleotide polymorphisms (SNPs) with susceptibility to bacterial infection within 6 months after orthotopic liver transplantation. This was a prospective cohort study of 113 consecutive LT recipients (n= 44 with infections; n= 69 without infection as controls) at the Shanghai Jiaotong University Affiliated First People Hospital (China) between January 2007 and January 2011. The association between TLR4 SNPs (rs1927907, rs1927914, rs11536889, rs1927906, and rs2149356) in recipients with the susceptibility to bacterial infection after orthotopic liver transplantation within 6 months was analyzed. A total of 44 transplant recipients (38.9%) developed bacterial infections within 6 months of LT, including 19 and 25 patients with Gram-positive and negative bacteria, respectively. Pulmonary infection (n= 21), cholangitis (n= 9), sepsis (n= 9), and other bacterial infections (n= 5) were observed. Recipient TLR4 rs1927907, rs1927914, rs11536889, and rs2149356 SNPs were associated with infections within 6 months after LT. Multivariate analysis showed that endotracheal intubation time >= 72 h (P=0.040, OR=2.84, 95% CI 1.05-7.70) and rs2149356 (AA vs. AC/CC, P=0.003, OR=4.24, 95% CI 1.65-10.93) were independently associated with bacterial infection within 6 months after LT. Kaplan-Meier analysis indicated that patients with the AA rs2149356 genotype could be at higher risk of developing a bacterial infection within 6 months after LT. Prolonged duration of endotracheal intubation and the TRL4 rs2149356 SNP were independently associated with infections after LT within 6 months.

• 出版日期2017
• 单位上海交通大学