Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay

作者：Ebrahimzadeh Mohammad Ali; Khalili Masoumeh^*; Jafari Negar; Zareh Giti; Farzin Davood; Amin Gholamreza

来源：Brazilian Journal of Pharmaceutical Sciences, 2018, 54(2).

DOI：10.1590/s2175-97902018000217363

• Crataegus pentaegyna
• Crataegus microphylla
• Antihypoxia/evaluation
• Circulatory hypoxia

The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and prolonged animal survival time. Anti-hypoia activity of C. pentaegyn was found to be superior to that of C. microphylla in circulatory and asphyctic hypoxia. Antihypoxic activity of these extracts may be attributed to their phenolic compounds.

• 出版日期2018