A promising dual mode SPECT/CT imaging platform based on Tc-99m-labeled multifunctional dendrimer-entrapped gold nanoparticles

作者：Wen, Shihui; Zhao, Lingzhou; Zhao, Qinghua; Li, Du; Liu, Changcun; Yu, Zhibo; Shen, Mingwu; Majoral, Jean-Pierre; Mignani, Serge; Zhao, Jinhua^*; Shi, Xiangyang^*

来源：Journal of Materials Chemistry B, 2017, 5(21): 3810-3815.

DOI：10.1039/c7tb00543a

• RAY COMPUTED-TOMOGRAPHY
• IN-VIVO
• OXIDE NANOPARTICLES
• CONTRAST AGENT
• RESONANCE
• DRUG
• PEPTIDE
• POLYETHYLENEIMINE
• NANOMATERIALS
• CHEMISTRY

Multifunctional Tc-99m-labeled dendrimer-entrapped gold nano-particles (Tc-99m-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the Tc-99m-Au DENPs, thereby allowing for preferential SPECT/CT imaging of different organs.

• 出版日期2017-6-7
• 单位上海交通大学; 东华大学