N-substituted amides as chiral ligands for catalytic asymmetric reactions

作者:Zhang J; Zhou HB; Xie RG*
来源:Current Organic Chemistry, 2002, 6(10): 865-890.
DOI:10.2174/1385272023373806

摘要

In this review we introduced many kinds of bifunctional N-substituted amides, including phosphinamides and phosphoramides, squaramides, sulfonamides and so on which were applied to the asymmetric reactions. More emphasis were given to the asymmetric borane reduction of prochiral ketones, the reaction conditions and mechanisms were discussed systematically. At the same time, other reactions, including asymmetric addition, Diels-Alder reaction and Aldol reactions catalyzed by chiral N-substituted amides were also reviewed.