Antiviral activity of hemocyanins

作者：Dolashka P^*; Voelter W

来源：Invertebrate Survival Journal, 2013, 10(1): 120-127.

• functional units
• hemocyanin
• mollusks
• arthropods
• viruses

Hemocyanins are giant biological macromolecules acting as oxygen-transporting glycoproteins. Most of them are respiratory proteins of arthropods and mollusks, but besides they also exhibit protecting effects against bacterial, fungal and viral invasions. As discovered by 2-DGE proteomics analyses, several proteins including hemocyanins of hemocytes from virus-infected arthropods increased upon infection, confirming hemocyanin%26apos;s role as part of the organism%26apos;s defence system. Based on the structural analyses of molluscan Hcs it is suggested that the carbohydrate chains of the glycoproteins seem to interact with surface-exposed amino acid or carbohydrate residues of the viruses through van der Waals interactions.

• 出版日期2013