Aryl hydrocarbon receptor and unexplained miscarriage

作者：Fan, Hongjie; Su, Xiaoling; Yang, Binlie; Zhao, Aimin^*

来源：Journal of Obstetrics and Gynaecology Research, 2017, 43(6): 1029-1036.

DOI：10.1111/jog.13309

• aryl hydrocarbon receptor
• decidua
• pregnancy
• unexplained miscarriage
• villus

Aim: The aim of this study was to carry out a preliminary investigation of the expression of aryl hydrocarbon receptor (AhR) in decidua and villus and the relationship between AhR and unexplained miscarriage.
Methods: The expression of AhR mRNA and protein from decidua and villus were measured using real-time reverse transcription-polymerase chain reaction, western blot and immunohistochemistry in 34 patients with unexplained miscarriage (miscarriage group) and 38 women with normal early pregnancy (control group).
Results: The AhR mRNA and protein expression was increased significantly in the villus in both groups compared with decidua (P < 0.05, P < 0.05). In decidua, AhR mRNA and protein expression in the miscarriage group was increased significantly compared with the control group (P < 0.05, P < 0.05). In villus, AhR mRNA and protein expression in the miscarriage group was increased significantly compared with the control group (P < 0.05, P < 0.05). AhR is expressed mostly in the cytoplasm of syncytiotrophoblasts in villus, and also in the cytoplasm of decidual cells.
Conclusions: AhR was expressed more in the villus than in the decidua, and the upregulation of AhR mRNA and protein expression is associated with the pathogenesis of unexplained miscarriage.

• 出版日期2017-6
• 单位上海市浦东新区人民医院; 上海交通大学