科研之友
微信
新浪微博
Facebook
分享链接
摘要
The condensation of tris(trimethylsilyl) phosphite with various ketimines leads directly to tetrasubstituted alpha-aminophosphonic acids. The presented reaction proceeds readily at room temperature and provides labile silylated esters of tetrasubstituted alpha-aminophosphonic acids, as non-isolable reaction intermediates. Subsequent methanolysis of the latter provides the desired alpha-aminophosphonic acids bearing an fully substituted alpha-carbon in good overall yields as crystalline non-hygroscopic solids after simple recrystallization from a methanol-acetone mixture.nordstom
- 出版日期2017
