Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix

作者：Reynes Barbara; Serrano Alba; Petrov Petar D; Ribot Joan; Chetrit Carles; Martinez Puig Daniel; Luisa Bonet M; Palou Andreu

来源：Journal of Functional Foods, 2016, 26: 350-362.

DOI：10.1016/j.jff.2016.07.022

• Glycosaminoglycans
• Weight loss
• Fat loss
• White adipose tissue
• Oxidative metabolism

The potential of a mixture of glycosaminoglycans (GAGs) contained in an oral supplement for joint discomfort (Oralvisc (TM)) to prevent diet-induced obesity (DIO) and to serve as co-adjuvant in weight loss strategies was studied. Oral treatment with the GAG mix did not counteract the development of DIO in obesity-prone mice but reduced food intake under normal fat diet and led to increased insulin sensitivity under both normal and high fat diets. During reversal of DIO, GAG-treated obese mice showed higher and faster loss of body fat and displayed decreased endpoint adiposity, leptinaemia and hepatic steatosis and signs of increased insulin sensitivity compared with vehicle-treated controls. Expression of oxidative metabolism-related genes and mitochondrial DNA content were increased in visceral white fat depots of GAG-treated animals. The results sustain this GAG mix in functional foods/supplements for obesity and particularly for the (frequent) combination of obesity and joint dysfunction symptoms.

• 出版日期2016-10