Toll-Like Receptor 2 R753Q Polymorphisms Are Associated With an Increased Risk of Infective Endocarditis

作者：Bustamante Juan^*; Tamayo Eduardo; Florez Santiago; Telleria Juan J; Bustamante Elena; Lopez Javier; San Roman J Alberto; Javier Alvarez F

来源：Revista Espanola de Cardiologia, 2011, 64(11): 1056-1059.

DOI：10.1016/j.rec.2011.02.027

• Innate immunity
• Single nucleotide polymorphism
• Toll-like receptor 2
• Infective endocarditis

The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by means of restriction analysis after their amplification. An association between endocarditis and variants of TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found. The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant (odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype. The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of infective endocarditis. Further studies are required to validate these results and identify other genetic risk factors.

• 出版日期2011-11