Multicenter Automatic Defibrillator Implantation Trial-Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

作者：Kutyifa Valentina^*; Beck Christopher; Brown Mary W; Cannom David; Daubert James; Estes Mark; Greenberg Henry; Goldenberg Ilan; Hammes Stephen; Huang David; Klein Helmut; Knops Reinoud; Kosiborod Mikhail; Poole Jeanne; Schuger Claudio; Singh Jagmeet P; Solomon Scott; Wilber David; Zareba Wojciech; Moss Arthur J

来源：American Heart Journal, 2017, 189: 158-166.

DOI：10.1016/j.ahj.2017.04.014

Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator.

• 出版日期2017-7