Antiproliferative, antioxidant, and antimutagenic activities of flavonoid-enriched extracts from (Tunisian) Rhamnus alaternus L.: Combination with the phytochemical composition

作者：Ben Ammar Rebai; Kilani Soumaya; Bouhlel Ines; Ezzi Lobna; Skandrani Ines; Boubaker Jihed; Ben Sghaier Mohamed; Naffeti Aicha; Mahmoud Amor; Chekir Ghedira Leila^*; Ghedira Kamel

来源：Drug and Chemical Toxicology, 2008, 31(1): 61-80.

DOI：10.1080/01480540701688725

• Rhamnus alatemus (Rhamnacae)
• antioxidant effect
• antimutagenic activity
• antiproliferative effect
• photochemical composition
• MII
• Ames test
• DPPH
• xanthine oxidase
• superoxide anions

A pronounced antiproliferative effect on human leukemia K562 cells was shown with flavonoid-enriched extracts from Rhamnus alaternus roots and leaves, with, respectively, IC50 values of 165 and 210.73 mu g/mL. High DPPH radical-scavenging activity (7.21 and 18.84 mu g/mL, respectively) and antioxidative effects using the xanthine oxidase assay (IC50 values of 83.33 and 103.96 mu g/mL, respectively) were detected in the presence of the two tested extracts. Although no mutagenic effect was observed when using the Salmonella typhimurium assay system with TA1535 and TA100 strains, the two tested extracts exhibited a high-level protection toward the direct mutagen, sodium azide-induced response.

• 出版日期2008