Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase

作者：Gordon Mark Forrest^*; Lenderking William R; Duhig Amy; Chandler Julie; Lundy J Jason; Miller David S; Piault Louis Elisabeth; Doody Rachelle S; Galasko Douglas; Gauthier Serge; Frank Lori

来源：Alzheimer's and Dementia, 2016, 12(1): 75-84.

DOI：10.1016/j.jalz.2015.04.008

• Cognition
• Mild cognitive impairment
• Alzheimer's disease
• Patient-reported outcome
• Activities of daily living
• Interpersonal functioning
• Qualitative
• Critical Path Institute

Introduction: As drug development research efforts move toward studying patients earlier in the course of Alzheimer's disease (AD), it is important to incorporate the patient's perspective into measurement of outcomes.
Methods: This article summarizes the qualitative work of the Patient-Reported Outcome Consortium's Cognition Working Group in the development of a new self-reported outcome measure in persons with mild cognitive impairment (MCI) due to suspected AD, herein referred to as MCI.
Results: The draft measure captures the patient's voice for two functional domains, complex activities of daily living and interpersonal functioning.
Discussion: This work represents a series of initial steps in the development of this rating scale. The next steps are to conduct psychometric analysis and evaluate the role of insight.

• 出版日期2016-1