As-72/74-labeling of HPMA based polymers for long-term in vivo PET imaging

作者：Herth Matthias M^*; Barz Matthias; Jahn Markus; Zentel Rudolf; Roesch Frank

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(18): 5454-5458.

DOI：10.1016/j.bmcl.2010.07.092

• As-72/74-labeling
• Long-term imaging
• PET
• Polymers

In the context of molecular imaging, various polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA) have been radio-labeled using longer-living positron emitters As-72 t(1/2) = 26 h or As-74 t(1/2) = 17.8 d. This approach may lead to non-invasive determination of the long-term in vivo fate of polymers by PET (positron emission tomography). Presumably, the radio label itself will not strongly influence the polymer structure due to the fact that the used nuclide binds to already existing thiol moieties within the polymer structure. Thus, the use of additional charges or bulky groups can be avoided.

• 出版日期2010-9-15