Pathologic Changes in Highly Myopic Eyes of Young Males in Singapore

作者：Koh Victor T C; Nah Gerard K M; Chang Lan; Yang Adeline H X; Lin Sheng Tong; Ohno Matsui Kyoko; Wong Tien Yin; Saw Seang Mei^*

来源：Annals Academy of Medicine Singapore, 2013, 42(5): 216-224.

DOI：10.47102/annals-acadmedsg.v42n5p216

• Optic disc
• retina
• Optical coherence tomography
• Pathological myopia

Introduction: This study describes the pathologic changes in the retina of a group of young Asian subjects with myopia worse than -10 diopters spherical equivalent (SE) refraction. Materials and Methods: The study population consists of 20 male subjects undergoing pre-employment screening for public service for a 1-year period from 2009 to 2010.A detailed series of visual tests of function, fundus examination and grading, ocular biometry and posterior segment optical coherence tomography were performed for all eyes. Results: A total of 21 eyes with mean SE of-10.88 diopters, [standard deviation (SD), 1.28 diopters], and mean age of 21.8 years (SD, 1.3 years) were included. Out of 21 eyes, 17(81.0%) had beta peripapillary atrophy, 10(47.6%) had clinically detectable optic disc tilt, 1(4.8%) had positive T-sign and 18 (85.7%) had retinal tessellation, 4 (19.0%) had posterior vitreous detachment and 14 (66.7%) had peripheral retina degeneration. The mean retinal nerve fibre layer (RNFL) thickness was 92.48 mm (SD, 9.99 mm). Conclusion: None of the 21 highly myopic eyes had features of myopic retinopathy but most of these young males had clinically visible myopia-associated abnormalities of the optic disc, vitreous and peripheral retina. Generally, these eyes had thinner RNFL. Further longitudinal studies are required to investigate if these eyes will eventually develop complications of pathological myopia.

• 出版日期2013-5