A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients

作者：Wadley A L^*; Kamerman P R; Chew C S N; Lombard Z; Cherry C L; Price P

来源：Molecular Immunology, 2013, 55(3-4): 197-199.

DOI：10.1016/j.molimm.2013.02.002

• Interleukin-4
• Cytokines
• HIV
• Neuropathy

Introduction: Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. %26lt;br%26gt;Method: 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. %26lt;br%26gt;Results: IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. %26lt;br%26gt;Discussion: We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation.

• 出版日期2013-10