FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

作者：Slebe Felipe; Rojo Federico; Vinaixa Maria; Garcia Rocha Mar; Testoni Giorgia; Guiu Marc; Planet Evarist; Samino Sara; Arenas Enrique J; Beltran Antoni; Rovira Ana; Lluch Ana; Salvatella Xavier; Yanes Oscar; Albanell Joan; Guinovart Joan J^*; Gomis Roger R^*

来源：Nature Communications, 2016, 7(1): 11199.

DOI：10.1038/ncomms11199

The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.

• 出版日期2016-4