A Pivotal Role for Interleukin-27 in CD8(+) T Cell Functions and Generation of Cytotoxic T Lymphocytes

作者：Morishima Noriko; Mizoguchi Izuru; Okumura Masae; Chiba Yukino; Xu Mingli; Shimizu Motomu; Matsui Masanori; Mizuguchi Junichiro; Yoshimoto Takayuki^*

来源：Journal of Biomedicine and Biotechnology, 2010, 605483.

DOI：10.1155/2010/605483

Cytotoxic T lymphocytes (CTLs) play a critical role in the control of various cancers and infections, and therefore the molecular mechanisms of CTL generation are a critical issue in designing antitumor immunotherapy and vaccines which augment the development of functional and long-lasting memory CTLs. Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, acts on naive CD4(+) T cells and plays pivotal roles as a proinflammatory cytokine to promote the early initiation of type-1 helper differentiation and also as an antiinflammatory cytokine to limit the T cell hyperactivity and production of proinflammatory cytokines. Recent studies revealed that IL-27 plays an important role in CD8(+) T cells as well. Therefore, this article reviews current understanding of the role of IL-27 in CD8(+) T cell functions and generation of CTLs.

• 出版日期2010
• 单位河北医科大学