Embedding clinical interventions into observational studies

作者：Newman Anne B^*; Aviles Santa M Larissa; Anderson Garnet; Heiss Gerardo; Howard Wm James; Krucoff Mitchell; Kuller Lewis H; Lewis Cora E; Robinson Jennifer G; Taylor Herman; Trevino Roberto P; Weintraub William

来源：Contemporary Clinical Trials, 2016, 46: 100-105.

DOI：10.1016/j.cct.2015.11.017

• Epidemiology
• Observational study
• Cohort
• Clinical trial
• Hybrid design

Novel approaches to observational studies and clinical trials could improve the cost-effectiveness and speed of translation of research. Hybrid designs that combine elements of clinical trials with observational registries or cohort studies should be considered as part of a long-term strategy to transform clinical trials and epidemiology, adapting to the opportunities of big data and the challenges of constrained budgets. Important considerations include study aims, timing, breadth and depth of the existing infrastructure that can be leveraged, participant burden, likely participation rate and available sample size in the cohort, required sample size for the trial, and investigator expertise. Community engagement and stakeholder (including study participants) support are essential for these efforts to succeed.

• 出版日期2016-1
• 单位NIH