Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: Cognitive, motor, sensory and behavioral function

作者：Rihtman Tanya^*; Parush Shula; Ornoy Asher

来源：Reproductive Toxicology, 2013, 41: 115-125.

DOI：10.1016/j.reprotox.2013.06.001

• Valproic acid
• Lamotrigine
• Monotherapy
• Intra-uterine AED exposure
• Developmental outcomes

This prospective, observational study assessed the development of preschool children aged 3-6 years, 11 months (n = 124) after in-utero anti-epileptic drug (AED) monotherapy exposure to valproic acid (VPA) (n = 30, mean age 52.00[+/- 15.22] months) and lamotrigine (LT) (n = 42, mean age 50.12[+/- 12.77] months), compared to non-exposed control children (n = 52, mean age 59.96[+/- 14.51] months). As a combined group, AED-exposed children showed reduced non-verbal IQ scores, and lower scores on motor measures, sensory measures, and parent-report executive function, behavioral and attentional measures. When the VPA- and LT-exposed groups were analyzed separately, no cognitive differences were found, but control-VPA and control-LT differences emerged for most motor and sensory measures as well as control-VPA parent-report behavioral and attentional differences. No differences were noted between the VPA and LT groups. These findings suggest that VPA- and LT-exposed children should be monitored on a wider range of developmental measures than currently used, and at differing developmental stages.

• 出版日期2013-11