Anti-HIV microRNA expression in a novel Indian cohort

作者：Dey Rakesh; Soni Kartik; Saravanan Shanmugam; Balakrishnan Pachamuthu; Kumar Vikram; Boobalan Jayaseelan; Solomon Sunil Suhas; Scaria Vinod; Solomon Suniti; Brahmachari Samir K; Pillai Beena^*

来源：Scientific Reports, 2016, 6(1): 28279.

DOI：10.1038/srep28279

HIV-1 replication inside host cells is known to be regulated by various host factors. Host miRNAs, by virtue of its normal functioning, also regulate HIV-1 RNA expression by either directly targeting virus mRNAs or indirectly by regulating host proteins that HIV-1 uses for own replication. Therefore, it is highly possible that with differential miRNA expression, rate of disease progression will vary in HIV-1 infected individuals. In this study we have compared expression of a panel of 13 reported anti-HIV miRNAs in human PBMCs from long term non progressors (LTNPs), regular progressors and rapid progressors. We found that LTNPs have substantial lower expression of miR-382-5p that positively correlates with viral loads. Combinatorial regulation is highly probable in dictating differential disease progression as average expression of miR-382-5p and miR-155-5p can substantially distinguish LTNP individuals from regular progressors.

• 出版日期2016-6-20