Mitochondrial dysfunction and the inflammatory response

作者：Lopez Armada Maria J^*; Riveiro Naveira Romina R; Vaamonde Garcia Carlos; Valcarcel Ares Marta N

来源：Mitochondrion, 2013, 13(2): 106-118.

DOI：10.1016/j.mito.2013.01.003

• Mitochondria
• Inflammation
• Aging
• Reactive oxygen species (ROS)
• Inflammasome
• Diet

Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter mitochondrial function. Both of these processes increase mitochondrial oxidative stress, promoting a vicious inflammatory cycle. Additionally, damage-associated molecular patterns derived from mitochondria could contribute to inflammasome formation and caspase-1 activation, while alterations in mitochondrial autophagy may cause inflammation. Strategies aimed at controlling excessive oxidative stress within mitochondria may represent both preventive and therapeutic interventions in inflammation.

• 出版日期2013-3