Antibacterial Compounds from Mushrooms I: A Lanostane-Type Triterpene and Prenylphenol Derivatives from Jahnoporus hirtus and Albatrellus flettii and Their Activities Against Bacillus cereus and Enterococcus faecalis

作者：Liu Xue Ting; Winkler Abby L; Schwan William R; Volk Thomas J; Rott Marc A; Monte Aaron^*

来源：Planta Medica, 2010, 76(2): 182-U81.

DOI：10.1055/s-0029-1186001

• Jahnoporus hirtus
• Albatrellus flettii
• Scutigeraceae
• triterpene
• prenylphenol
• antibacterial

Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24(Z)-diene-26-oic acid (1) from J. hirtus and confluentin (2), grifolin (3), and neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1-4 demonstrated MIC values of 40, 20, 10, and 20 mu g/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 mu g/mL, respectively, against E. faecalis. Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.

• 出版日期2010-1