Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir

作者：Chun Tae Wook^*; Murray Danielle; Justement Jesse S; Blazkova Jana; Hallahan Claire W; Fankuchen Olivia; Gittens Kathleen; Benko Erika; Kovacs Colin; Moir Susan; Fauci Anthony S

来源：Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(36): 13151-13156.

DOI：10.1073/pnas.1414148111

• latent HIV
• HIV-specific antibodies
• HIV envelope protein

Several highly potent and broadly neutralizing monoclonal antibodies against HIV have recently been isolated from B cells of infected individuals. However, the effects of these antibodies on the persistent viral reservoirs in HIV-infected individuals receiving antiretroviral therapy (ART) are unknown. We show that several HIV-specific monoclonal antibodies-in particular, PGT121, VRC01, and VRC03-potently inhibited entry into CD4(+) T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by ART. In addition, we demonstrate that HIV replication in autologous CD4(+) T cells derived from infected individuals receiving ART was profoundly suppressed by three aforementioned and other HIV-specific monoclonal antibodies. These findings have implications for passive immunotherapy as an approach toward controlling plasma viral rebound in patients whose ART is withdrawn.

• 出版日期2014-9-9
• 单位NIH