A transcriptional profile of the decidua in preeclampsia

作者：Loset Mari^*; Mundal Siv B; Johnson Matthew P; Fenstad Mona H; Freed Katherine A; Lian Ingrid A; Eide Irina P; Bjorge Line; Blangero John; Moses Eric K; Austgulen Rigmor

来源：American Journal of Obstetrics and Gynecology, 2011, 204(1): 84.e1.

DOI：10.1016/j.ajog.2010.08.043

• decidua
• genomewide gene expression
• microarray
• preeclampsia

OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis.
STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks.
RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were over-represented canonical pathways.
CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved.

• 出版日期2011-1