Brain sonography insight into the midbrain in myotonic dystrophy type 2

作者：Rakocevic stojanovic Vidosava; Peric Stojan; Savic pavicevic Dusanka; Pesovic Jovan; Mesaros Sarlota; Lavrnic Dragana; Jovanovic Zagorka; Pavlovic Aleksandra

来源：Muscle & Nerve, 2016, 53(5): 700-704.

DOI：10.1002/mus.24927

<jats:title>ABSTRACT</jats:title><jats:p><jats:italic>Introduction</jats:italic>: The aim of this study was to analyze transcranial sonography (TCS) findings in genetically confirmed myotonic dystrophy type 2 (DM2) patients. <jats:italic>Methods</jats:italic>: Forty DM2 patients and 38 gender‐ and age‐matched healthy controls (HCs) underwent TCS through the pre‐auricular acoustic bone <jats:italic>Results</jats:italic>: Substantia nigra hyperechogenicity was found in 20% of DM2 patients compared with 3% of HCs. Brainstem raphe (BR) hypoechogenicity was more common in DM2 patients compared with HCs (56% vs. 10%, <jats:italic>P</jats:italic> &lt; 0.01), and it was more common in patients with fatigue and excessive daytime sleepiness (<jats:italic>P</jats:italic> &lt; 0.05). Diameter of the third ventricle was increased in DM2 patients compared with HCs (5.8 ± 1.7 vs. 5.1 ± 1.0 mm, <jats:italic>P</jats:italic> &lt; 0.05). <jats:italic>Conclusions</jats:italic>: Finding BR hypoechogenicity might have clinical implication because of the potential response to serotonin‐reuptake inhibitors. TCS revealed alterations in brain structures previously not seen in MRI studies. <jats:italic>Muscle Nerve</jats:italic> <jats:bold>53</jats:bold>: 700–704, 2016</jats:p>

• 出版日期2016-5