Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

作者：Sashidhara Koneni V^*; Palnati Gopala Reddy; Dodda Ranga Prasad; Sonkar Ravi; Khanna A K; Bhatia Gitika

来源：European Journal of Medicinal Chemistry, 2012, 57: 302-310.

DOI：10.1016/j.ejmech.2012.09.040

• Amide based fibrates
• Antidyslipidemic
• Triton model
• Antioxidant activity

A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia.

• 出版日期2012-11