Asymmetric Synthesis of 2-Heteroaryl Cyclic Amines: Total Synthesis of (-)-Anabasine

作者：Sallio Romain; Lebrun Stephane; Gigant Nicolas; Gillaizeau Isabelle^*; Deniau Eric

来源：European Journal of Organic Chemistry, 2014, 2014(20): 4381-4388.

DOI：10.1002/ejoc.201402202

• Synthetic methods
• Asymmetric synthesis
• Chiral auxiliaries
• Cross-coupling
• Amines

A new and concise method for the synthesis of enantioenriched 2-heteroaryl cyclic amines was developed through an intramolecular chirality transfer. The influence of the nature of both ring size and heteroaryl moiety was investigated. The versatility of this reaction was demonstrated by the enantioselective synthesis of (-)-anabasine.

• 出版日期2014-7