α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

作者：Lei, Jianjun; Huo, Xiongwei; Duan, Wanxing; Xu, Qinhong; Li, Rong; Ma, Jiguang; Li, Xuqi; Han, Liang; Li, Wei; Sun, Hao^*; Wu, Erxi; Ma, Qingyong

来源：Cancer Letters, 2014, 347(1): 129-138.

DOI：10.1016/j.canlet.2014.02.003

• alpha-Mangostin
• PSC
• Hypoxia
• ROS
• Pancreatic cancer

Recent advances indicating a key role of microenvironment for tumor progression, we investigated the role of PSCs and hypoxia in pancreatic cancer aggressiveness, and examined the potential protective effect of a-mangostin on hypoxia-driven pancreatic cancer progression. Our data indicate that hypoxic PSCs exploit their oxidative stress due to hypoxia to secrete soluble factors favouring pancreatic cancer invasion. a-Mangostin suppresses hypoxia-induced PSC activation and pancreatic cancer cell invasion through the inhibition of HIF-1 alpha stabilization and GLI1 expression. Increased generation of hypoxic ROS is responsible for HIF-1 alpha stabilization and GLI1 upregulation. Therefore, alpha-mangostin may be beneficial in preventing hypoxia-induced pancreatic cancer progression.

• 出版日期2014-5-28
• 单位西安交通大学