Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

作者：Jensen Brian C; O'Connell Timothy D; Simpson Paul C^*

来源：Journal of Molecular and Cellular Cardiology, 2011, 51(4): 518-528.

DOI：10.1016/j.yjmcc.2010.11.014

• alpha-1-Adrenergic receptors
• Cardiac myocytes
• Heart failure
• Drug development

Evidence from cell, animal, and human studies demonstrates that alpha 1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and beta-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating alpha 1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure." Published by Elsevier Ltd.

• 出版日期2011-10