Amyloid-beta Positron Emission Tomography Imaging Probes: A Critical Review

作者：Kepe Vladimir; Moghbel Mateen C; Langstrom Bengt; Zaidi Habib; Vinters Harry V; Huang Sung Cheng; Satyamurthy Nagichettiar; Doudet Doris; Mishani Eyal; Cohen Robert M; Hoilund Carlsen Poul F; Alavi Abass; Barrio Jorge R^*

来源：Journal of Alzheimer's Disease, 2013, 36(4): 613-631.

DOI：10.3233/JAD-130485

• Amyloid imaging
• amyloid %26apos
• specific%26apos
• imaging probes
• Amyvid
• critical review
• neuropathologic criteria
• PIB
• silent medial temporal lobe

The rapidly rising prevalence and cost of Alzheimer%26apos;s disease in recent decades has made the imaging of amyloid-beta deposits the focus of intense research. Several amyloid imaging probes with purported specificity for amyloid-beta plaques are currently at various stages of FDA approval. However, a number of factors appear to preclude these probes from clinical utilization. As the available %26quot;amyloid specific%26quot; positron emission tomography imaging probes have failed to demonstrate diagnostic value and have shown limited utility for monitoring therapeutic interventions in humans, a debate on their significance has emerged. The aim of this review is to identify and discuss critically the scientific issues contributing to the extensive inconsistencies reported in the literature on their purported in vivo amyloid specificity and potential utilization in patients.

• 出版日期2013