Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women

作者：Korkmaz Ugur^*; Korkmaz Nurdan; Yazici Selma; Erkan Melih; Baki Ali Erdem; Yazici Mehmet; Ozhan Hakan; Ataoglu Safinaz

来源：European Journal of Internal Medicine, 2012, 23(2): 154-158.

DOI：10.1016/j.ejim.2011.11.009

• Bone mineral density
• Dual-energy X-ray absorptiometry
• Hemoglobin
• Postmenopausal women

Background: We investigated the association of bone mineral density (BMD) by detected dual-energy X-ray absorptiometric (DXA) method and hemoglobin (Hb) levels in a large sample.
Methods: The current study enrolled 371 postmenopausal women (82 anemic patients), who were screened for osteopenia or osteoporosis by DXA. Patients with osteopenia or osteoporosis (T score < -1.0 SD) were grouped as having low bone mass (LBM).
Results: Anemic patients were older and had significantly higher duration of menopause. When compared with subjects with normal Hb, anemic patients had significant lower femur t score, femur BMD, femur Z score, spinal t score, spinal BMD and spinal Z score (p<0.001). Additionally, the ratio of subjects with LBM in the femur and spine were significantly high in anemic patients (p<b0.002, p<0.002, respectively). There were significant correlations between Hb values and femur t score, femur BMD, spine t score, and spine BMD values of the study population in bivariate correlation analysis (r=0.150, p=0.004, r=0.148, p=0.004, r=0.160, p=0.002, r=0.164, p=0.001, respectively). Furthermore, presence of anemia was found to be an independent predictor of LBM for spine [OR: 2.483 (95% CI: 1.309-4.712), p<0.005] in logistic regression analysis. Additionally, number of anemic patients was significantly high in low femur and spine BMD groups (56 vs. 26; p=0.01, 66 vs. 16; p=0.002, respectively).
Conclusion: We have found that the presence of anemia was as an independent predictor of LBM for spine after adjusting for body mass index and other confounders in postmenopausal Turkish women.

• 出版日期2012-3